A scaling-down experiment system of array laterolog resistivity was developed, and a corresponding formation model was built by 3D finite element numerical method to study the effect of different factors on the logging response quantitatively. The error between the experimental and numerical results was less than 5%, validating the reliability of the numerical simulation method. The single factor analysis of the formation relative dip, resistivity anisotropy and drilling fluid invasion was carried out by numerical simulation method, and the results show that: (1) The increase of relative dip can lead to the increase of formation resistivity, but the increasing value is relatively small, and the values of five array resistivity curves will reverse when the relative dip angle reaches a certain degree. (2) The increase of anisotropy coefficient λ can also cause the formation resistivity to rise, and the resistivity will increase by about 10% when λ increases from 1.0 to 1.5 in vertical wells. (3) Drilling fluid invasion has a more significant effect on the logging response than the former two factors. The order of the five curves will change due to drilling fluid invasion in anisotropic formation and the change rule is contrary to resistivity anisotropy. Taking the logging data of the Yingxi oilfield in the Qaidam Basin as an example, an anisotropic formation model considering drilling fluid invasion was built, and the numerical simulation results from the above methods were basically consistent with the logging data, which verified the accuracy of the method again. The results of this study lay a theoretical foundation for multiple-parameter inversion in anisotropic formation under complex well conditions.