Organic reef reservoirs in the platform margin of Kaijiang-Liangping trough in Damaoping area, Sichuan Basin are thin in single layer, fast in lateral variation, and have small P-impedance difference from the surrounding rock, it is difficult to identify and predict the reservoirs and fluid properties by conventional post-stack inversion. Through correlation analysis of core test data and logging P-S wave velocity, this work proposed a formula to calculate the shear wave velocity in different porosity ranges, and solved the issue that some wells in the study area have no S-wave data. AVO forward analysis reveals that formation porosity is the main factor affecting the variation of AVO type, the change of water saturation cannot affect the AVO type, but it has an effect on the change range of AVO. Through cross-plotting analysis of elastic parameters, it is found that fluid factor is a parameter sensitive to gas-bearing property of organic reef reservoir in the study area. By comparing results of post-stack impedance inversion, post-stack high frequency attenuation property, pre-stack simultaneous inversion and AVO anomaly analysis of angle gathers, it is found that the gas-bearing prediction of organic reef reservoirs by using fluid factor derived from simultaneous pre-stack inversion had the highest coincidence rate with actual drilling data. At last, according to the characteristics of fluid factor distribution, the favorable gas-bearing area of the organic reef reservoir in Changxing Formation was predicted, and the organic reef trap at the top of Changxing Formation in Block A of Damaoping area was sorted out as the next exploration target.