By means of thin section analysis, zircon U-Pb dating, scanning electron microscopy, electron probe, laser micro carbon and oxygen isotope analysis, the lithologic features, diagenetic environment evolution and controlling factors of the tight sandstone reservoirs in the Huagang Formation of Xihu sag, East China Sea Basin were comprehensively studied. The results show that: the sandstones of the Huagang Formation in the central inverted structural belt are poor in physical properties, dominated by feldspathic lithic quartz sandstone, high in quartz content, low in matrix, kaolinite and cement contents, and coarse in clastic grains; the acidic diagenetic environment formed by organic acids and meteoric water is vital for the formation of secondary pores in the reservoirs; and the development and distribution of the higher quality reservoirs in the tight sandstones of the Huagang Formation are controlled by sediment source, sedimentary facies belt, abnormal overpressure and diagenetic environment evolution. Sediment provenance and dominant sedimentary facies led to favorable initial physical properties of the sandstones in the Huagang Formation, which is the prerequisite for development of reservoirs with better quality later. Abnormal high pressure protected the primary pores, thus improving physical properties of the reservoirs in the Huagang Formation. Longitudinally, due to the difference in diagenetic environment evolution, the high-quality reservoirs in the Huagang Formation are concentrated in the sections formed in acidic diagenetic environment. Laterally, the high-quality reservoirs are concentrated in the lower section of the Huagang Formation with abnormal high pressure in the middle-northern part; but concentrated in the upper section of Huagang Formation shallower in burial depth in the middle-southern part.