To deal with the stress interference caused by simultaneous propagation of multiple fractures and the wettability reversal and physical property changes of the reservoir caused by fracturing fluid getting in during large-volume fracturing of tight oil reservoirs through a horizontal well, a non-planar 3D fracture growth model was built, wettability reversal characterizing parameters and change of relative permeability curve were introduced to correct the production prediction model of fractured horizontal well, a fracturing design optimization software (FrSmart) by integrating geological and engineering data was developed, and a fracturing design optimization approach for tight oil reservoirs based on fracture control was worked out. The adaptability of the method was analyzed and the fracture parameters of horizontal wells in tight oil reservoirs were optimized. The simulation results show that fracturing technology based on fracture control is suitable for tight oil reservoirs, and by optimizing fracture parameters, this technology makes it possible to produce the maximum amount of reserves in the well-controlled unit of unconventional reservoirs. The key points of fracturing design optimization based on fracture control include increasing lateral length of and reducing the row spacing between horizontal wells, increasing perforation clusters in one stage to decrease the spacing of neighboring fractures, and also avoiding interference of old and new fracturing wells. Field tests show that this technology can increase single well production and ultimate recovery. Using this technology in developing unconventional resources such as tight oil reservoirs in China will enhance the economics significantly.